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If health is a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity, then what makes a city healthy? This issue explores numerous aspects related to this broader question: How city planning and architecture directly affect human health from a medical perspective. Why marginalisation and social segregation is a dominant factor in this regard. Why our attitudes to the natural environment are crucial to our urban well-being. How indigenous approaches can enhance sprawling post-industrial cities. How progressive approaches to architecture and urbanism can encourage walkability, sustainability and local food production. How intelligent policies can overturn petrified trends that compromise both human and ecological well-being. And more. This second issue of My Liveable City during the COVID-19 pandemic year redirects our attention to how our collective well-being is directly related to and dependent on the manner in which we shape our cities and towns.